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Research Article: Diagnostic Value and Clinical Application of Metagenomic Next-Generation Sequencing for Infections in Critically Ill Patients

Date Published: 2023-09-25

Introduction:
Infection is one of the greatest challenges for critically ill patients and intensivists. Previous investigations reported that % to % of antimicrobials used in ICUs are unnecessary, inappropriate, or suboptimal, , which might be partly attributed to the many defects of conventional microbiological tests (CMT). Culture is the most commonly used method to identify bacteria and fungi, but some species are fastidious or even unculturable, which leads to a low detection rate. Even worse, the use of antimicrobial…

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