Research Article: Correlation of Coagulation Dysfunction with Infection and Hypercapnia in Acute Exacerbation of COPD Patients

Abstract:
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable chronic airway disease that is characterized by persistent airflow restriction and corresponding respiratory symptoms; its pathological changes are mainly airway and/or alveolar abnormalities, which are usually related to significant exposure to harmful particles or gases, genetic susceptibility, abnormal inflammatory response, abnormal lung development, and other host factors participating in pathogenesis., Academician Chen Wang et al reveal that, at present, the overall prevalence of COPD among people aged and over in China is .%, of which the prevalence among people aged and over is .%; it is estimated that nearly million people in China have COPD. COPD patients suffer .–. times more each year from acute exacerbation, and the average hospitalization cost per person is up to , yuan, which has seriously increased the economic burden of patients and society. The early inflammatory response of COPD is confined to the trachea and lungs, but in the course of the disease, hypoxia and chronic inflammation affect the whole body. When respiratory failure occurs in patients with acute exacerbation of COPD (AECOPD), circulatory and coagulation dysfunction often occurs, which is considered to be the cause of thrombotic events. Furthermore, abnormal coagulation and thrombosis may accelerate the progress of COPD, resulting in prolonged hospitalization, high hospitalization costs, poor prognosis, and even increased mortality.

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