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Research Article: A Meta-Analysis of the Antidepressant Responses in Pivotal Trials on Esketamine Nasal Spray and Atypical Antipsychotics

Date Published: 2023-12-27

Introduction:
Major depressive disorder (MDD) is the leading cause of disability worldwide. In the US, the -month prevalence of MDD is .%, and the lifetime prevalence is .%. About –% of individuals with MDD ultimately manifest treatment-resistant depression (TRD). Although no universal definition currently exists, health authorities generally define TRD as a failure to achieve response during the current major depressive episode following at least two different antidepressant treatments administered at an adequate dose and…

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