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Research Article: .–% Supramolecular Salicylic Acid Hydrogel is Safe for Long-Term Topical Application and Improves the Expression of Genes Related to Skin Barrier Homeostasis in Mice Models

Date Published: 2023-05-26

Abstract:
The skin barrier, which is essential for preserving homeostasis, enables the skin to resist hazardous substances from the external environment (i.e., the outside-in barrier) and to prevent excessive loss of water and electrolytes from the body (i.e., the inside-out barrier). Maintaining the integrity and wellness of the body requires a well-balanced cutaneous barrier. A vicious cycle of inflammation and the emergence of skin illnesses like atopic dermatitis may arise if the barrier system is disrupted and not compensated for.,

Introduction:
The skin barrier, which is essential for preserving homeostasis, enables the skin to resist hazardous substances from the external environment (i.e., the outside-in barrier) and to prevent excessive loss of water and electrolytes from the body (i.e., the inside-out barrier). Maintaining the integrity and wellness of the body requires a well-balanced cutaneous barrier. A vicious cycle of inflammation and the emergence of skin illnesses like atopic dermatitis may arise if the barrier system is disrupted and not…

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