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Research Article: Generation of a CD-Specific Fusion Nanobody with IgG Recruiting Capacity for Tumor Killing

Date Published: 2023-06-19

Introduction:
In the past decade, immunotherapy has made great progress in the treatment of hematological and solid cancers by targeting immune checkpoint molecules such as CTLA-, PD-, and PD-L . However, the clinical application of cancer immunotherapy is quite limited due to the existing primary, adaptive, and acquired resistance, and only a minority of patients benefit from the therapy. Therefore, there is a need to develop novel targets for immunotherapy.

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