Research Article: Evaluation of Trace Elements Levels and Construction of Auxiliary Prediction Model in Patients with Diabetes Ketoacidosis in Type Diabetes
Abstract:
Type diabetes (TD) is an endocrine disorder in which pancreatic ? cells stop producing insulin, typically due to autoimmune destruction. This long-term autoimmune destruction will lead to insulinopenia, followed by hyperglycemia and the breakdown of insulin-dependent processes of cellular energy storage and synthesis., Accelerated glycogenolysis and lipolysis will provide substrates for ketogenesis through the breakdown of triacylglycerol from fat and the increase of circulating plasma amino acids., In addition, ?-cell glucagon production will be enhanced by loss of the paracrine suppressive effect exerted by ?-cells,, and glucagon shifts hepatic intracellular metabolism towards production of ketones. These relatively strong metabolic acids will cause the accumulation of hydrogen ions, and the buffering capacity of the kidney will be quickly exceeded, resulting in the development of metabolic acidosis and the morbidity of ketoacidosis (DKA).
Introduction:
Type diabetes (TD) is an endocrine disorder in which pancreatic ? cells stop producing insulin, typically due to autoimmune destruction. This long-term autoimmune destruction will lead to insulinopenia, followed by hyperglycemia and the breakdown of insulin-dependent processes of cellular energy storage and synthesis. , Accelerated glycogenolysis and lipolysis will provide substrates for ketogenesis through the breakdown of triacylglycerol from fat and the increase of circulating plasma amino acids. , In addition,…
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