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Research Article: A Prospective Case-Control Study Examining the Relationship Between Frailty and Serum Myostatin in Older Persons with Chronic Heart Failure

Date Published: 2023-07-20

Abstract:
Frailty is defined as a clinical state of growing vulnerability and functional impairment caused by a cumulative decline in several bodily systems, which raises the likelihood of unfavorable health outcomes, such as falls, hospitalization, and death., Although old age increases the probability of acquiring frailty,, frailty does not directly relate to chronologic age or impairment. A widely diverse population, older persons have varying levels of health and functional life spans. The scientific interest in fragility as a potential explanation for the disparity in health among older persons is growing. Frailty is thought to affect % of community-dwelling persons > years of age in the USA. Frailty and/or functional decline are highly related with advanced age, poverty and/or isolation, polypharmacy, malnutrition and/or weight loss, cognitive impairment, and medical and/or psychiatric co-morbidities. Frailty is typically chronic and progressive, but interventions may improve outcomes or potentially reverse the frailty status., Frailty is becoming a silent killer that primarily affects elderly adults.,

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