Research Article: Tacrolimus Trough Level Variation and Its Correlation to Clinical Outcomes and Consequences in Solid Organ Transplantation
Introduction:
Tacrolimus (TAC) has been the primary agent as immunosuppressive agent in solid organ transplants since the s. It is a potent calcineurin inhibitor that suppresses cellular immunity by inhibiting T-lymphocyte activation where it has a significant contribution to considerable five-year survival rates after a solid organ transplant. , Compared to the other calcineurin inhibitor, cyclosporine, TAC is known to provide higher organ and patient survival rates. Therefore, it leads to lower rejection rates and higher span…
Read more