why choose us

300×250 Ad Slot

Research Article: The Impact of Inhaled Corticosteroids on the Prognosis of Chronic Obstructive Pulmonary Disease

Date Published: 2023-05-02

Abstract:
Although chronic obstructive pulmonary disease (COPD) has been a major public health concern and was expected to rank third among all the causes of death by , there is still no therapeutic intervention that modifies the natural course of COPD., The pharmacological treatment of COPD comprises long-acting muscarinic antagonist (LAMA), long-acting beta-agonists (LABA), the combination of LAMA and LABA, the combination of LABA and inhaled corticosteroids (ICS), and triple therapy including LABA, LAMA, and ICS. The benefits of ICS in COPD reported by various studies include the reduction of frequency of COPD exacerbations, a lower rate of hospitalization, and a reduction of all-cause mortality in some COPD subgroups.– However, the use of ICS in COPD is much debated because of the associated safety concerns;– there is a concern about the attendant side effects of ICS on COPD including pneumonia and tuberculosis., Consequently, the withdrawal of ICS in COPD patients is common due to ICS-related adverse events or treatment-related risks outweighing the expected benefits., In addition, ICS treatment is associated with several challenges; observational studies suggested that overprescription of ICS is common in patients with COPD and smoking can result in steroid resistance by decreasing the efficacy of ICS in COPD.,,

Introduction:
Although chronic obstructive pulmonary disease (COPD) has been a major public health concern and was expected to rank third among all the causes of death by , there is still no therapeutic intervention that modifies the natural course of COPD. , The pharmacological treatment of COPD comprises long-acting muscarinic antagonist (LAMA), long-acting beta-agonists (LABA), the combination of LAMA and LABA, the combination of LABA and inhaled corticosteroids (ICS), and triple therapy including LABA, LAMA, and ICS. The…

Read more

300×250 Ad Slot