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Research Article: SARS-CoV- N Protein Triggers Acute Lung Injury via Modulating Macrophage Activation and Infiltration in in vitro and in vivo

Date Published: 2023-04-28

Abstract:
SARS-CoV--induced disease is still a huge healthy burden worldwide. Although the latest variant causes less severe cases, acute respiratory distress syndrome (ARDS) or even multi-organ failure or death due to this virus infection can still be seen daily.– The SARS-CoV- induced acute lung injury, as an initial organ injury, is characterized with diffuse alveolar damage in early phase and epithelial cell losing repairing ability towards respiratory failure in late phase in severe cases., The complex pathophysiological process suggests that SARS-CoV- infection dysregulates the host response and induces immuno-inflammatory and parenchymal derangements, but the mechanistic basis of lung injury remains incompletely understood.

Introduction:
SARS-CoV--induced disease is still a huge healthy burden worldwide. Although the latest variant causes less severe cases, acute respiratory distress syndrome (ARDS) or even multi-organ failure or death due to this virus infection can still be seen daily. – The SARS-CoV- induced acute lung injury, as an initial organ injury, is characterized with diffuse alveolar damage in early phase and epithelial cell losing repairing ability towards respiratory failure in late phase in severe cases. , The complex…

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