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Research Article: Hepatitis B Virus-Encoded MicroRNA (HBV-miR-) Inhibits FIH- Expression to Promote Tumor Angiogenesis in HBV-Related Hepatocellular Carcinoma

Date Published: 2023-12-27

Introduction:
Hepatocellular carcinoma (HCC) is a solid tumor with abundant blood supply, and angiogenesis is involved in the process of HCC development. , Most HCCs in China are related to hepatitis B virus infection. In previous studies, hepatitis B virus (HBV) was confirmed to promote the progression of angiogenesis of HCC by the HBV X protein (HBx) and small protein of hepatitis B virus surface antigens (SHBs). HBx increases the protein level of HIF-? by direct binding with HIF-?, thus leading to the decrease of interaction…

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