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Research Article: A Prospective Observational Study of Children with FS-Associated Hospitalization: The Implication and Outcomes of Pathogen Detection in Cerebrospinal Fluid

Date Published: 2023-05-18

Abstract:
Febrile seizures (FS) are one of the major neurological emergencies that require prompt diagnosis and treatment. Most cases are benign but may be associated with multiple clinical sequelae, including a higher risk of epilepsy and FS recurrence. If this acute condition is not adequately evaluated and treated at the time of first presentation, the opportunities to alter the poor prognosis may be missed. Identifying the cause of fever is the first task in the assessment of such children. FS caused by infections of respiratory or intestinal systems have been well recognized.– However, evidence on central nervous system (CNS) pathogens in children with primary symptom of seizure accompanied with fever is limited, which creates a risk of confusion between FS and other CNS disorders. Over the past decade, nucleic acid amplification tests have been used to clinically diagnose various common causes of meningitis. If cultures of suspected encephalitis/meningitis remain negative, highly sensitive PCR or multiplex-PCR can be used to amplify conserved regions of pathogenic DNA/RNA to identify the causative organism.– The aim of this study was to investigate the role of common CNS pathogens in CSF specimens from FS-associated hospitalized children and to identify susceptibility factors and specific characteristics of children who tested positive for CSF.

Introduction:
Febrile seizures (FS) are one of the major neurological emergencies that require prompt diagnosis and treatment. Most cases are benign but may be associated with multiple clinical sequelae, including a higher risk of epilepsy and FS recurrence. If this acute condition is not adequately evaluated and treated at the time of first presentation, the opportunities to alter the poor prognosis may be missed. Identifying the cause of fever is the first task in the assessment of such children. FS caused by infections of…

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