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Research Article: An Exploratory Study of Sleep-Wake Differences of Autonomic Activity in Patients with Mild Cognitive Impairment: The Role of Melatonin as a Modulating Factor

Date Published: 2023-05-12

Introduction:
Mild cognitive impairment (MCI) has been defined as an intermediate state between healthy ageing and dementia, where patients exhibit clinically significant mild cognitive decline from expected performance for subjects’ age group, yet not severe enough to impact functional independence in activities of daily living. MCI is present in –% of older adults over years old and % of MCI subjects convert to dementia due to Alzheimer’s disease (AD) (the main cause for dementia) over a five-year period. For this reason, MCI…

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