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Research Article: How National Health Insurance Coverage Policy Affected the Use of Trastuzumab and Rituximab in China: A Bicentric Retrospective Study

Date Published: 2023-09-04

Abstract:
Female breast cancer (BC) was the leading cause of cancer incidence (. million cases, .% of total cases) and the fifth leading cause of cancer mortality (, cases) worldwide in . According to the World Health Organization (WHO), China will have more new cases and deaths from BC than any other Asian country in , with , new cases and , deaths. Trastuzumab, is a humanized monoclonal antibody that targets the extracellular domain of the human epidermal growth factor receptor (HER) protein. It was the first anti-HER agent approved by the US Food and Drug Administration (FDA) for clinical use and has become a standard of treatment for patients with HER-positive breast cancer when combined with chemotherapy., Non-Hodgkin lymphoma (NHL) caused , new cases and , deaths in , according to the GLOBOCAN database. A systematic assessment of the burden of lymphoma in China revealed that the burden of NHL in China increased much higher than the global burden. NHL caused a large burden of cancer incidence and mortality in men, and it was ranked as one of the top ten most common cancer types in Chinese males. Rituximab, a humanized monoclonal antibody against CD and the first monoclonal antibody approved for the treatment of lymphoma, has become the standard first-line treatment and maintenance therapy for NHL. Although innovative targeted therapies have substantially revolutionized the treatment of certain cancers, these targeted anticancer drugs frequently come with high costs, thereby escalating the financial burden on patients and healthcare insurance systems.

Introduction:
Female breast cancer (BC) was the leading cause of cancer incidence (. million cases, .% of total cases) and the fifth leading cause of cancer mortality (, cases) worldwide in . According to the World Health Organization (WHO), China will have more new cases and deaths from BC than any other Asian country in , with , new cases and , deaths. Trastuzumab, is a humanized monoclonal antibody that targets the extracellular domain of the human epidermal growth factor receptor (HER) protein. It was the first anti-HER…

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