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Research Article: Lipoxin A Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis via Promoting the Regression of Inflammation

Date Published: 2023-08-08

Introduction:
Psoriasis is manifested by excessive hyperplasia of keratinocytes of the epidermis, accompanied by extensive infiltration of inflammatory cells into the epidermis and dermis. Typical histologic features include hyperkeratosis, parakeratosis, and formation of neutrophil microabscesses (also known as Munro microabscesses) in the areas of parakeratosis; the granular layer is significantly reduced or disappeared, the muscular layer above the dermal papilla becomes thinner, with elongated capillaries, and clinical…

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