Research Article: Association of Dietary Acid Load with Nonalcoholic Fatty Liver Disease and Advanced Liver Fibrosis in US Adults: Evidence from NHANES –
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is defined as lipid buildup of more than % in hepatocytes in the absence of other contributing factors to liver injury, with a disease spectrum ranging from simple steatosis to nonalcoholic steatohepatitis characterized by associated inflammation and fibrosis, and a fraction of patients may progress to cirrhosis and hepatocellular carcinoma. NAFLD is now the most common chronic liver disease worldwide (~ in adults have NAFLD), and its prevalence and incidence have dramatically risen over the past few decades and have emerged as the leading cause of liver transplantation., In addition, NAFLD is a multisystem disease that is closely linked not only to metabolic diseases such as obesity and diabetes, but also to the development of other clinical entities such as cardiovascular disease (CVD), chronic kidney disease, and depression. Despite the substantial public health burden associated with NAFLD, there are still no FDA-approved drug therapies for the treatment of NAFLD.
Introduction:
Nonalcoholic fatty liver disease (NAFLD) is defined as lipid buildup of more than % in hepatocytes in the absence of other contributing factors to liver injury, with a disease spectrum ranging from simple steatosis to nonalcoholic steatohepatitis characterized by associated inflammation and fibrosis, and a fraction of patients may progress to cirrhosis and hepatocellular carcinoma. NAFLD is now the most common chronic liver disease worldwide (~ in adults have NAFLD), and its prevalence and incidence have…
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