Research Article: Integrated Analysis of Non-Coding RNA and mRNA Expression Profiles in Exosomes from Lung Tissue with Sepsis-Induced Acute Lung Injury
Abstract:
Acute lung injury (ALI) is a devastating condition with a high morbidity rate among critically ill patients. Although there have been significant advances in the treatment of ALI in recent years, it remains a life-threatening disease with a high mortality rate (–%).– Histologically, ALI is characterized by acute pulmonary inflammation, which severely impairs lung function. Evidence suggests that overactivation of inflammatory cells, such as macrophage, may lead to adverse pulmonary inflammation, and subsequently, to ALI., Macrophages are important effector cells for host defense against foreign stimuli and are important in the pathogenesis of pulmonary inflammation and ALI., Once activated, M macrophages release inflammatory cytokines and regulate the influx of leukocyte chemokines.
Introduction:
Acute lung injury (ALI) is a devastating condition with a high morbidity rate among critically ill patients. Although there have been significant advances in the treatment of ALI in recent years, it remains a life-threatening disease with a high mortality rate (–%). – Histologically, ALI is characterized by acute pulmonary inflammation, which severely impairs lung function. Evidence suggests that overactivation of inflammatory cells, such as macrophage, may lead to adverse pulmonary inflammation, and subsequently,…
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