Research Article: Pathogen Diagnosis Value of Nanopore Sequencing in Severe Hospital-Acquired Pneumonia Patients
Abstract:
Severe hospital-acquired pneumonia (SHAP) is the most common acquired infection in the intensive care unit (ICU) and one of the main causes of increased mortality in ICU patients., Potential multidrug-resistant pathogens are very common in ICU-acquired pneumonia, including Pseudomonas aeruginosa, Acinetobacter spp., methicillin-resistant Staphylococcus aureus (MRSA), and ultrabroad spectrum ?-lactamase (ESBL)-producing and carbapenem-resistant Enterobacteriaceae (CRE). Timely and appropriate antibiotic treatment is effective in reducing patient mortality, but it often takes up to hours from respiratory sampling to the acquisition of definitive microbiological test results, which leads to untimely antibiotic therapy and increased mortality. Therefore, early identification of the pathogen and timely use of targeted antibiotics is particularly important to improve prognosis.
Introduction:
Severe hospital-acquired pneumonia (SHAP) is the most common acquired infection in the intensive care unit (ICU) and one of the main causes of increased mortality in ICU patients. , Potential multidrug-resistant pathogens are very common in ICU-acquired pneumonia, including Pseudomonas aeruginosa, Acinetobacter spp., methicillin-resistant Staphylococcus aureus (MRSA), and ultrabroad spectrum ?-lactamase (ESBL)-producing and carbapenem-resistant Enterobacteriaceae (CRE). Timely and appropriate antibiotic treatment…
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