Research Article: Comprehensive Analysis to Identify Rh Family C Glycoprotein (RHCG) as the Causative Gene for Psoriasis and Search for Alternative Treatment Modalities
Abstract:
Psoriasis, a chronic recurrent skin disease triggered by environmental factors, has an incidence of about two percent. The underlying pathogenesis of psoriasis stems from a complex interplay among immune cells, skin cells and many cytokines. The prevailing view is that abnormal expression of cytokines, including tumor necrosis factor (TNF) and interleukins (IL), leads to over-proliferation of keratinocytes and dysfunction of the immune system, which ultimately induces the visible skin phenotype.
Introduction:
Psoriasis, a chronic recurrent skin disease triggered by environmental factors, has an incidence of about two percent. The underlying pathogenesis of psoriasis stems from a complex interplay among immune cells, skin cells and many cytokines. The prevailing view is that abnormal expression of cytokines, including tumor necrosis factor (TNF) and interleukins (IL), leads to over-proliferation of keratinocytes and dysfunction of the immune system, which ultimately induces the visible skin phenotype.
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