Research Article: Evaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling
Abstract:
Patient-reported penicillin allergy is associated with inappropriate prescribing, antibiotic resistance, and adverse outcomes.1 Various clinical decision-making tools for penicillin allergy have been developed to guide antibiotic selection and delabeling strategies,1-3 yet further validation is required to promote their use. PEN-FAST is a clinical decision-making tool with a high negative predictive value (NPV) that can identify patients with low-risk penicillin allergy who do not require skin testing prior to oral penicillin challenge.1 We aimed to validate PEN-FAST in risk stratification of reported penicillin allergies at a large tertiary health care system outside of the country in which it was developed to further promote PEN-FAST use and enhance global penicillin allergy delabeling.
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