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Research Article: Pharmacologically Treated Anxiety and Depression in People Diagnosed with von Willebrand Disease: Matched Cohort Study

Date Published: 2023-07-11

Abstract:
von Willebrand factor is a clotting protein that mediates platelet functions and stabilizes clotting factor VIII. Congenital von Willebrand disease (VWD) is characterized by impaired function or reduced levels of von Willebrand factor, and is the most common inherited bleeding disorder globally (prevalence of – per , individuals). The prevalence of symptomatic disease requiring treatment is, however, much lower ( per ,). VWD bleeding phenotypes vary depending on disease type, age, and sex. Common symptoms include bruising, epistaxis, bleeding from wounds or surgeries, joint and mucocutaneous bleeding, and menorrhagia.– Rare and potentially life-threatening bleeding can occur in the central nervous system and gastrointestinal tract.,

Introduction:
von Willebrand factor is a clotting protein that mediates platelet functions and stabilizes clotting factor VIII. Congenital von Willebrand disease (VWD) is characterized by impaired function or reduced levels of von Willebrand factor, and is the most common inherited bleeding disorder globally (prevalence of – per , individuals). The prevalence of symptomatic disease requiring treatment is, however, much lower ( per ,). VWD bleeding phenotypes vary depending on disease type, age, and sex. Common symptoms include…

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