Research Article: The Use of an Iterative Strategy of Cognitive Interview and Expert Consultation to Revise the Quality of Life Scale for Patients with Aplastic Anemia (QLS-AA)
Abstract:
Aplastic anaemia (AA) is a rare, life-threatening and heterogeneous disorder. It is defined as pancytopenia with a hypocellular bone marrow in the absence of an abnormal infiltrate or marrow fibrosis. The excessive apoptosis of hematopoietic stem cells caused by cytotoxic T cells and/or lymphokines is the main pathogenesis of acquired AA. The incidence of AA in the United States and Europe is below ./million, while the incidence of AA in Asia is – times higher., In China, the annual incidence of AA is ./ population, and has a biphasic distribution, with peaks at – years and over years. Anemia, hemorrhage and infection are the initial manifestations of AA, and with the development of the disease, the clinical symptoms are gradually worsen, which may be accompanied by refractory anemia, multi-organ hemorrhage and sepsis, which pose a great threat to their life and health.,
Introduction:
Aplastic anaemia (AA) is a rare, life-threatening and heterogeneous disorder. It is defined as pancytopenia with a hypocellular bone marrow in the absence of an abnormal infiltrate or marrow fibrosis. The excessive apoptosis of hematopoietic stem cells caused by cytotoxic T cells and/or lymphokines is the main pathogenesis of acquired AA. The incidence of AA in the United States and Europe is below ./million, while the incidence of AA in Asia is – times higher. , In China, the annual incidence of AA is ./…
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