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Research Article: Decreased Sphingosine Due to Down-Regulation of Acid Ceramidase Expression in Airway of Bronchiectasis Patients: A Potential Contributor to Pseudomonas aeruginosa Infection

Date Published: 2023-04-28

Introduction:
Bronchiectasis is a chronic purulent disease of the airways causing permanent dilatation of the bronchi and bronchioles; this predisposes the patient to opportunistic infections, the most common being Pseudomonas aeruginosa ( P. aeruginosa ). When the microbial diversity of sputum in bronchiectasis patients decreases, P. aeruginosa infection predominates, increasing the risk of disease severity and death. , Impaired airway flora homeostasis and damaged airway epithelium might increase the susceptibility to P.…

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