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Research Article: Potential Anti-Toxoplasmosis Efficiency of Phoenix dactylifera Extracts Loaded on Selenium Nanoparticles

Date Published: 2023-12-20

Abstract:
Toxoplasmosis is a parasite illness produced by Toxoplasma gondii that affects humans and many types of mammals and birds. This parasite has a sexual life cycle, which takes place in the small intestine of cats, and an asexual cycle that takes place in warmed animals and humans., Humans become infected by eating raw and undercooked meat and through the ingestion of contaminated vegetables and fruits. The other possible routes of transmission can be from the placenta to the embryo during pregnancy in humans, which can cause serious health problems. The symptoms of toxoplasmosis are diverse, although immunocompetent patients may have light symptoms such as fever, headache, and muscle pain or be asymptomatic. However, serious clinical manifestations involving the central nervous system (CNS) may also be observed in immunocompromised patients., T. gondii is a neurotropic obligate intracellular parasite. By infiltrating, reproducing in, and lysing endothelial cells, T. gondii tachyzoites are able to cross the blood-brain barrier (BBB) and get access to the brain. The BBB failure is then further exacerbated by the activated microglia emit pro-inflammatory cytokines.

Introduction:
Toxoplasmosis is a parasite illness produced by Toxoplasma gondii that affects humans and many types of mammals and birds. This parasite has a sexual life cycle, which takes place in the small intestine of cats, and an asexual cycle that takes place in warmed animals and humans. , Humans become infected by eating raw and undercooked meat and through the ingestion of contaminated vegetables and fruits. The other possible routes of transmission can be from the placenta to the embryo during pregnancy in humans, which…

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