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Research Article: HucMSC-Exo Promote Mucosal Healing in Experimental Colitis by Accelerating Intestinal Stem Cells and Epithelium Regeneration via Wnt Signaling Pathway

Date Published: 2023-05-25

Abstract:
The inflammatory bowel diseases, typically categorized as ulcerative colitis and Crohn’s disease, are chronic non-specific intestinal disorders. Although the lack of a comprehensive understanding of its underlying pathophysiological mechanisms, it is widely accepted that the interplay between genetic susceptibility, environmental factors and microbial dysbiosis, which mediates dysregulated immune responses, results in the relapsing intestinal inflammation and prolonged mucosal damage.

Introduction:
The inflammatory bowel diseases, typically categorized as ulcerative colitis and Crohn’s disease, are chronic non-specific intestinal disorders. Although the lack of a comprehensive understanding of its underlying pathophysiological mechanisms, it is widely accepted that the interplay between genetic susceptibility, environmental factors and microbial dysbiosis, which mediates dysregulated immune responses, results in the relapsing intestinal inflammation and prolonged mucosal damage.

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