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Research Article: Development and Validation of an Algorithm for Thrombosis with Thrombocytopenia Syndrome (TTS) at Unusual Sites

Date Published: 2023-06-15

Introduction:
Passive safety surveillance, case series, and observational studies reported the occurrence of thrombosis with thrombocytopenia syndrome (TTS), including thromboses that occurred at unusual sites (ie intracranial or cerebral, and intraabdominal thromboses), after receipt of adenoviral vector-based COVID- vaccines, noting that no such association with COVID- mRNA vaccines has been established. While a standard case definition for TTS does not yet exist, an interim definition from the Brighton Collaboration defines…

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