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Research Article: Efficacy and safety of acupuncture for post-COVID-19 depression: a protocol for systematic review and meta-analysis

Date Published: 2023-05-11

Abstract:
Introduction Post-COVID-19 depression (PCD) is a possible sequela of COVID-19. Some doctors have used acupuncture to treat PCD, but no systematic review or meta-analysis has yet evaluated its efficacy and safety for the treatment of PCD. The aim of this systematic review is to assess the efficacy and safety of acupuncture therapy for PCD. Methods and analysis Two reviewers will independently search the Cochrane Central Register of Controlled Trials (CENTRAL), Medline (PubMed), Excerpt Medica Database (EMBASE), China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Chinese Scienti?c Journal Database (VIP) and Wan-Fang Database from inception to 24 January 2023. Study selection, data extraction and assessment of study quality will be independently performed by two reviewers. If a meta-analysis is appropriate, Review Manager V.5.3 will be used for data synthesis; otherwise, a descriptive analysis will be conducted. Data will be synthesised using a ?xed-effects or random-effects model, according to the results of a heterogeneity test. The results will be presented as risk ratios with 95% CIs for dichotomous data, and weighted mean differences or standardised mean differences with 95% CIs for continuous data. Ethics and dissemination The entire process used for this systematic review does not use private information, so ethical approval is not required. The results of this meta-analysis will be disseminated through publication in a peer-reviewed journal and/or conference presentations. PROSPERO registration number CRD42022379312.

Introduction:
The SARS-CoV-2 virus is responsible for the worldwide COVID-19 pandemic during the past 3?years. Hundreds of millions of people around the world have been infected with this virus, and approximately 80% of patients who were hospitalised for COVID-19 have experienced post-COVID-19 sequelae. The main postacute sequelae are fatigue and cognitive impairment, and the other long-lasting neuropsychiatric disorders include depression 1 and certain physical manifestations, such as dyspnoea. These symptoms can persist for…

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