Research Article: Rationale and Design of the Rivaroxaban Post-Transradial Access for the Prevention of Radial Artery Occlusion Trial (CAPITAL-RAPTOR)
Abstract:
Introduction Transradial access (TRA) has rapidly emerged as the preferred vascular access site for coronary angiography and percutaneous coronary intervention. Radial artery occlusion (RAO) remains as an important complication of TRA as it precludes future ipsilateral transradial procedures. While intraprocedural anticoagulation has been studied extensively, the definitive role of postprocedural anticoagulation has not yet been established. Methods and analysis The Rivaroxaban Post-Transradial Access for the Prevention of Radial Artery Occlusion trial is a multicentre, prospective, randomised, open-label, blinded-endpoint design study investigating the efficacy and safety of rivaroxaban to reduce the incidence of RAO. Eligible patients will undergo randomisation to receive either rivaroxaban 15?mg once daily for 7?days or to no additional postprocedural anticoagulation. Doppler ultrasound to assess radial artery patency will be performed at 30 days. Ethics and dissemination The study protocol has been approved by the Ottawa Health Science Network Research Ethics Board (approval number 20180319-01H). The study results will be disseminated via conference presentations and peer-reviewed publications. Trial registration number NCT03630055 .
Introduction:
Transradial access (TRA) has rapidly emerged as the preferred vascular access site for coronary angiography (CA) and percutaneous coronary intervention (PCI). 1 Advantages of TRA include rapid haemostasis, early ambulation after the procedure thereby improving patient comfort and experience and decrease length of stay. 2 There is also a reduction in all-cause mortality, major adverse cardiovascular events, major bleeding and vascular complications with TRA as compared with transfemoral access (TFA), 3 4 which has…
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