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Research Article: Descriptive registry study on outcome and complications of external ventricular drainage treatment of intraventricular haemorrhage in a Danish cohort: a study protocol

Date Published: 2024-01-18

Abstract:
Introduction Intraventricular haemorrhage (IVH) is associated with high morbidity and mortality. External ventricular drainage (EVD) has been shown to decrease mortality. Although EVD is widely used, outcome and complication rates in EVD-treated patients with IVH are not fully elucidated. This study aims to describe EVD complication rates and outcomes in patients with primary and secondary IVH at two university hospitals in Denmark. The study will provide a historical reference of relevant endpoints for use in future clinical trials involving patients with IVH. Methods and analysis This descriptive, multicentre registry study included adult patients (age 18+) with primary or secondary IVH and treated with at least one EVD between 2017 and 2021 at Aarhus University Hospital or Odense University Hospital. Patients are identified using the Danish National Patient Register. Data are collected and recorded from patient medical records. Relevant descriptive statistics and correlation analyses will be applied. Ethics and dissemination Ethical approval and authorisation to access, store and analyse data have been obtained (Central Denmark Region Committee on Health Research Ethics). The research lead will present the results of the study. Data will be reported according to the Strengthening the Reporting of Observational Studies in Epidemiology and results submitted for publication in peer-reviewed journals.

Introduction:
Intracerebral haemorrhage (ICH) is associated with high mortality or severe, long-term neurological disability. 1–3 The incidence of ICH is 24.6 per 100?000 person years, 4 5 and approximately 10% suffer an intraventricular haemorrhage (IVH). IVH is associated with higher mortality and neurological morbidity than haemorrhages with no intraventricular extension. 6–9 Patients with IVH have a high risk of hydrocephalus and increased intracranial pressure (ICP). 10 11 Current IVH treatment involves extensive…

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