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Research Article: Rotavirus-Associated Hospitalization in Children With Subsequent Autoimmune Disease

Date Published: 2023-07-26

Abstract:
Importance  Rotavirus infection is a common cause of gastroenteritis in children that can trigger autoimmune processes, but the nature of this interaction remains poorly understood. Objective  To estimate the association of rotavirus infection with the risk of subsequent autoimmune disease. Design, Setting, and Participants  This population-matched cohort study used data from children and adolescents (aged younger than 18 years) in South Korea (national registers from January 1, 2002, to December 31, 2017). The cohort consisted of 86?157 patients in the exposure group who had experienced rotavirus-associated hospitalization and the same number of matched patients in the unexposed group. Data analyses were from May 1, 2020, through October 20, 2022. Exposures  Hospitalization for rotavirus infection.

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