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Research Article: How Will Our Practice Change After the CLEAR Outcomes Trial?

Date Published: 2024-01-31

Introduction:
Clinical trials have consistently demonstrated that lowering levels of low-density lipoprotein cholesterol (LDL-C) produces reductions in cardiovascular event rates in high risk patients [1,2,3,4,5,6,7,8,9, 10••]. The results of these trials have transformed approaches to the prevention of cardiovascular disease [11, 12]. However, the finding that many individuals fail to achieve the degree of LDL-C lowering required for effective risk reduction suggests that additional approaches are required. This has led to the…

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