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Research Article: Despite Recovery from Necrotizing Enterocolitis Infants Retain a Hyperinflammatory Response to Injury

Date Published: 2024-01-17

Abstract:
Necrotizing enterocolitis (NEC) is a devastating disease of premature neonates characterized by significant intestinal injury with severe morbidity and mortality., There are well-established associations with the disease including prematurity, early enteral feeding with formula feeds, intestinal barrier disruption, and an unregulated hyperinflammatory response., Despite these known associations and significant advances in care for these neonates, pathogenesis remains incompletely understood.,,

Introduction:
Necrotizing enterocolitis (NEC) is a devastating disease of premature neonates characterized by significant intestinal injury with severe morbidity and mortality. , There are well-established associations with the disease including prematurity, early enteral feeding with formula feeds, intestinal barrier disruption, and an unregulated hyperinflammatory response. , Despite these known associations and significant advances in care for these neonates, pathogenesis remains incompletely understood. , ,

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