Research Article: A Novel LDLC Equation is Superior to the NIH LDLC Equation and the Friedewald Equation
Abstract:
A lipid panel that includes triglycerides (TGs), total cholesterol (TC), high-density lipoprotein (HDL) cholesterol (HDLC), and low-density lipoprotein (LDL) cholesterol (LDLC) is used worldwide for routine testing to determine your cholesterol status. Routinely, the LDLC level is estimated by calculation using a formula (eg, the NIH LDLC (LDL_NIH) equation and the Friedewald (LDL_F) equation). However, direct measurement of LDLC is not a routine cholesterol test. Research indicates that the direct measurement of LDLC is important for information about CVD risk. However, its advantages are modest when comparing it to LDLC levels calculated using a formula. Because the LDLC calculated formula is a reliable and cost-effective method for routine cholesterol tests, the LDLC calculated formula still needs to be optimized and improved. We read with interest an article titled “Validating the LDL_NIH equation in a specialized lipid cohort: Does it add up?” by Victoria Higgins et al that was published in Clinical Biochemistry. The authors focused on which calculation equation is better for LDLC and concluded that the LDL_NIH equation was superior to the LDL_F equation based on ultracentrifugation LDLC. Is this true? It can be seen from the cohort of equations we established that the LDLC calculated by the LDL_NIH and LDL_F equations is lower than that measured by the direct method (Table ).
Table The Characteristics of Establishment of the LDLC Equation Group
Introduction:
A lipid panel that includes triglycerides (TGs), total cholesterol (TC), high-density lipoprotein (HDL) cholesterol (HDLC), and low-density lipoprotein (LDL) cholesterol (LDLC) is used worldwide for routine testing to determine your cholesterol status. Routinely, the LDLC level is estimated by calculation using a formula (eg, the NIH LDLC (LDL_NIH) equation and the Friedewald (LDL_F) equation). However, direct measurement of LDLC is not a routine cholesterol test. Research indicates that the direct measurement of…
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