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Research Article: Immunological Features of Children with Gastrointestinal Bleeding Due to Henoch-Schönlein Purpura

Date Published: 2024-01-23

Abstract:
Henoch-Schönlein purpura (HSP), also called IgA vasculitis (IgAV), is the most common form of systemic vasculitis in childhood. HSP is characterized by widespread leukocytoclastic vasculitis of small vessels resulting from vascular entrapment of circulating immunoglobulin A (IgA) immune complexes with complement activation., The reported incidence varied from to per , children, and the incidence could reach per , Asian children with a peak incidence of five years., The clinical features of HSP include non-thrombocytopenic purpura, arthritis, arthralgia, gastrointestinal (GI) disorders, and renal involvement. About two-thirds of children with HSP have abdominal pain with or without abdominal distension, nausea, vomiting, and GI bleeding., Although GI bleeding accounts for about –% of HSP abdominal symptoms, it threatens children’s lives.,, Furthermore, massive intestinal bleeding is associated with a significantly increased mortality., Some children with severe or refractory GI bleeding require long-term nutritional support and treatment. This leads to substantially increased medical costs and longer hospital stays. Consequently, early detection of GI bleeding is crucial for HSP treatment and prognosis.

Introduction:
Henoch-Schönlein purpura (HSP), also called IgA vasculitis (IgAV), is the most common form of systemic vasculitis in childhood. HSP is characterized by widespread leukocytoclastic vasculitis of small vessels resulting from vascular entrapment of circulating immunoglobulin A (IgA) immune complexes with complement activation. , The reported incidence varied from to per , children, and the incidence could reach per , Asian children with a peak incidence of five years. , The clinical features of HSP include…

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