Research Article: Population Pharmacokinetics and Model-Based Dose Optimization of Vancomycin in Sudanese Adult Patients with Renal Impairment
Introduction:
Vancomycin is a first-line therapy for methicillin-resistant Staphylococcus aureus (MRSA), and therapeutic drug monitoring (TDM) is performed to reduce the risk of nephrotoxicity and assure optimal therapeutic outcomes. Several organizations have produced clinical practice recommendations to guide TDM of vancomycin. , The minimum inhibitory concentration (MIC) of vancomycin against MRSA continues to rise due to its extensive use. On the other hand, vancomycin’s pharmacokinetic (PK) parameters have wide variability…
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