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Research Article: Real-World Effectiveness Study of Nirmatrelvir-Ritonavir or Molnupiravir in Hospitalized Unvaccinated Patients with Chronic Respiratory Diseases and Moderate COVID- at Presentation

Date Published: 2024-01-09

Introduction:
The introduction of oral antivirals nirmatrelvir-ritonavir (NMV-r) and molnupiravir (MOL) against COVID- allows successful outpatient management of COVID-. – NMV-r is a combination of oral protease inhibitors, with nirmatrelvir blocking the activity of the SARS-CoV--CL protease and coadministration with ritonavir slows the metabolism of nirmatrelvir so it remains active in the body for longer and at higher concentrations. MOL is a nucleoside analog that inhibits SARS-CoV- replication by inducing lethal mutations…

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