Research Article: Association of magnesium depletion score with serum anti-aging protein Klotho in the middle-aged and older populations
Abstract:
Background: Magnesium deficiency and low levels of the anti-aging protein Klotho have been independently associated with various age-related diseases. The Magnesium Depletion Score (MDS) is recognized as a more valuable and reliable predictor of body magnesium status than traditional clinical markers such as serum and urine magnesium. However, the relationship between magnesium status and serum Klotho levels remains unexplored. This study aimed to investigate the association between magnesium depletion, as quantified by MDS, and serum Klotho levels in US adults.
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