why choose us

300×250 Ad Slot

Research Article: Construction of a nomogram model for predicting vaginal birth after induction of labor in pregnant women with fetal growth restriction at term

Date Published: 2026-01-28

Abstract:
The study aimed to develop and validate a predictive nomogram model of vaginal delivery in women with fetal growth restriction (FGR) who undergo labor induction. A retrospective cohort study was conducted at Fujian Maternity and Child Health Hospital, involving 507 singleton pregnancies complicated with fetal growth restriction (FGR) between October 2017 and December 2022. These pregnancies underwent labor induction with dinoprostone or Cook’s double balloon. The cohort was randomly divided into two groups: 75% of pregnancies ( n = 380) were utilized to identify independent factors associated with vaginal delivery using multi-logistic regression and develop a predictive nomogram model, while 25% ( n = 127) were allocated for internal validation of the model. A predictive nomogram model was constructed with five validated factors including maternal age, multiparity, oligohydramnios (borderline significant), Bishop score after cervical ripening and Cook’s double balloon. The trained and validated area under the curve were 0.811 (95% confident interval 0.757–0.865) and 0.760 (95% confident interval 0.669–0.860), respectively. The Hosmer-Lemeshow test indicated no statistically significant difference between the predicted and observed outcomes ( P > 0.050). The clinical decision curve demonstrated that both the model and the validation groups achieved the greatest net benefit at threshold probability values ranging from 0.20 to 0.95 and exceeding 0.40, respectively. The nomogram model could be utilized to inform patients with FGR about their success of vaginal delivery during labor induction. Moreover, this model established a foundation for clinical intervention and the development of personalized medical treatment strategies.

Introduction:
Fetal growth restriction (FGR) is a condition in which the fetus does not achieve its biological growth potential, affecting approximately 10% of cases ( 1 ). FGR is a significant contributor to infant morbidity and mortality, ranking second only to premature birth. Furthermore, FGR has been associated with long-term complications including impaired neurodevelopment and cardiovascular disease(s) in adulthood ( 2 ). Estimated fetal weight (EFW) was calculated using the Hadlock IV formula ( 3 ), and FGR was defined…

Read more

300×250 Ad Slot