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Opto-CD28-REACT: optogenetic co-stimulatory receptor activation on non-engineered human T cells

Abstract: T-cell activation is a highly regulated process requiring both antigen recognition via the T-cell receptor (TCR) and co-stimulatory signaling, notably through the…

Date: 2025-09-19

Blinatumomab demonstrates MRD eradication in MRD-positive/chemotherapy-delayed pediatric B-ALL and high response in relapsed/refractory cases: a multicenter cohort study

Abstract: Blinatumomab, a bispecific T-cell engager targeting CD3+ and CD19+, promotes T cell–mediated cytotoxicity against B-cell precursor acute lymphoblastic leukemia (B-ALL).…

Date: 2025-09-18

Single-cell profiling uncovers PTPRG-driven stemness in malignant plasma cells and signatures of treatment failure in multiple myeloma

Abstract: Multiple myeloma (MM) is characterized by extensive intratumoral heterogeneity and complex interactions within the bone marrow microenvironment, yet the cellular and…

Date: 2025-09-18

Association between triglyceride-glucose index and sarcopenia in patients with chronic kidney disease

Abstract: This study aimed to examine the relationship between the triglyceride-glucose index (TyG) and sarcopenia in patients with chronic kidney disease (CKD). The aim was to…

Date: 2025-09-18

Trends in commercial complementary food in Romanian infants–a cross-sectional study

Abstract: Good feeding practices beginning early in life and are crucial for preventing all forms of malnutrition and non-communicable diseases. This time frame encompasses the…

Date: 2025-09-18

Epidemiology and clinical aspect of pediatric mushroom poisonings: a 15-year retrospective analysis

Abstract: Mushroom poisoning is a significant public health concern, particularly in pediatric populations, where developmental differences in toxin metabolism and organ…

Date: 2025-09-18

Follicular fluid-derived small extracellular vesicles during individual in vitro maturation improve blastocyst development

Abstract: We evaluated the impact of follicular fluid-derived small extracellular vesicles (FF-sEVs) supplementation during oocyte maturation in vitro on bovine embryo outcomes,…

Date: 2025-09-18

Estimation of the current healthcare costs of gout in Liaoning Province from 2015 to 2022 based on the SHA2011 accounting system

Abstract: Gout has become a major public health problem worldwide, causing severe pain, discomfort, inflammation, mobility problems and impaired physical functioning, resulting in…

Date: 2025-09-18

Heterogeneity of benefit finding in maintenance hemodialysis patients: a decision tree-based subgroup analysis of self-efficacy and social support

Abstract: Benefit finding (BF) improves quality of life in maintenance hemodialysis (MHD) patients, yet population heterogeneity remains understudied. This study explores how…

Date: 2025-09-18

Management of severe pneumonia in respiratory non-intensive care unit: a retrospective study from a single center experience

Abstract: Severe pneumonia management in the hospital setting often relies heavily on established clinical practice and physician experience. This approach has the purpose of…

Date: 2025-09-18