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PRMT6 inhibitors promote fracture healing by modulating osteoclast glucose metabolism

Abstract: Impaired fracture healing remains a significant clinical challenge due to the complexity of the healing process. Osteoclasts, derived from monocytes, are pivotal in bone…

Date: 2025-09-18

Intrathecal injection of bone marrow concentrate in children with autism spectrum disorder: a retrospective chart analysis

Abstract: The growing prevalence of autism spectrum disorder (ASD) underscores the urgent need for therapies that target underlying biological mechanisms, with cell-based…

Date: 2025-09-18

Global, regional, and national burden of hip fractures attributable to falls in older adults: changes from 1990–2021 and 2036 projections

Abstract: Hip fractures attributable to falls (HFAF) represent one of the life-threatening conditions in older adults. This study aims to analyze trends and geographical…

Date: 2025-09-18

Burden and trends of major depressive disorders among women of childbearing age and the impact of the COVID-19 pandemic: insights from the global burden of disease study 2021

Abstract: Major depressive disorder (MDD) exhibits a pronounced female predominance, contributing substantially to disability-adjusted life-years (DALYs) among women of…

Date: 2025-09-18

Preliminary study on BRICS sequential therapeutic regimen as salvage treatment for refractory advanced colorectal cancer patients harboring pMMR status

Abstract: Patients with refractory mismatch repair-proficient/microsatellite stable (pMMR/MSS) metastatic colorectal cancer exhibit intrinsic resistance to immune checkpoint…

Date: 2025-09-18

Assessing the impact of enteral nutrition on peripancreatic exudate in acute pancreatitis using CT volume measurement

Abstract: To investigate the effect of enteral nutrition (EN) on peripancreatic exudate in MSAP and SAP patients using CT volume measurement. This retrospective study included 328…

Date: 2025-09-18

The impact of airway management guided by Protection Motivation Theory on the prevention and prognosis of post-stroke pneumonia

Abstract: Stroke remains a leading cause of morbidity and mortality worldwide, with post-stroke pneumonia significantly impacting patient outcomes. Despite progress in stroke…

Date: 2025-09-18

Heterologous prime-boost vaccination with VLA2001 and an ORFV-based vector enhances spike- and nucleocapsid-specific immunity in mice

Abstract: Heterologous prime–boost vaccination has emerged as a promising approach to enhance immune responses by combining vaccines with complementary mechanisms of antigen…

Date: 2025-09-18

Integration of autophagy-related genes and immune dysregulation reveals a prognostic landscape in multiple myeloma

Abstract: Autophagy is a self-renewal mechanism in which cells degrade damaged organelles or abnormal proteins through lysosomes. This process eliminates harmful components within…

Date: 2025-09-17

Association between eating behavior patterns and the therapeutic efficacy of GLP-1 receptor agonists in individuals with type 2 diabetes: a multicenter prospective observational study

Abstract: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used to improve glycemic control and induce weight loss in individuals with type 2 diabetes (T2D), yet…

Date: 2025-09-17