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Development and validation of a product acceptability questionnaire for intranasal Q-Griffithsin COVID-19 prophylaxis (SPRAY PAL)

Abstract: Objectives Patient experiences are critical when determining the acceptability of novel interventional pharmaceuticals. Here, we report the development and validation of…

Date: 2023-09-12

Development of the TrAnsparent ReportinG of observational studies Emulating a Target trial (TARGET) guideline

Abstract: Background Observational studies are increasingly used to inform health decision-making when randomised trials are not feasible, ethical or timely. The target trial…

Date: 2023-09-12

Association of neck circumference-related indices with metabolic, atherogenic and liver function biomarkers in patients with non-alcoholic fatty liver disease: a cross-sectional study

Abstract: Objective The present study aimed to establish the association of neck circumference (NC)-related indices with metabolic, atherogenic and liver function biomarkers in…

Date: 2023-09-12

Mortality and failure-to-rescue major complication trends after lung cancer surgery between 2005 and 2020: a nationwide population-based study

Abstract: Objectives To estimate the evolution of quality indicators (30-day mortality and failure-to-rescue) inpatients who underwent lung cancer surgery in France over the past…

Date: 2023-09-12

Facilitators of and barriers to patient and public involvement in building learning health systems in community health services settings: a scoping review protocol

Abstract: Introduction The development of learning health systems (LHSs) has often focused on optimally leveraging data. More attention should be paid to patient and public…

Date: 2023-09-12

Long-course chemoradiation plus concurrent/sequential PD-1 blockade as neoadjuvant treatment for MMR-status-unscreened locally advanced rectal cancer: protocol of a multicentre, phase 2, randomised controlled trial (the POLAR-STAR trial)

Abstract: Introduction Recent preclinical studies have discovered unique synergism between radiotherapy and immune checkpoint inhibitors, which has already brought significant…

Date: 2023-09-12

Development of practice-based quality indicators for the primary care of older adults: a RAND/UCLA Appropriateness Method study protocol

Abstract: Introduction Older adults have high rates of primary care utilisation, and quality primary care has the potential to address their complex medical needs. Family…

Date: 2023-09-12

Study of How Adiposity in Pregnancy has an Effect on outcomeS (SHAPES): protocol for a prospective cohort study

Abstract: Introduction Maternal obesity increases the risk of multiple maternal and infant pregnancy complications, such as gestational diabetes and pre-eclampsia. Current UK…

Date: 2023-09-12