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Bendopnea as an independent prognostic marker for adverse events in hospitalized heart failure patients: insights from a multicenter prospective cohort study

Abstract: Heart failure (HF) remains a leading cause of cardiovascular morbidity and mortality globally, affecting over 64 million individuals ( 1 ). Despite advancements in…

Date: 2025-09-24

REDD1 attenuates cholestatic liver fibrosis and suppresses PI3K/AKT/mTOR pathway

Abstract: Liver fibrosis is reversible. Cholestasis is an important factor causing liver fibrosis. However, there are currently no effective anti-fibrotic drugs for cholestatic…

Date: 2025-09-24

Diagnostic efficacy of magnifying endoscopy with blue laser imaging for laryngopharyngeal reflux

Abstract: We aimed to analyze the utility of magnifying endoscopy with blue laser imaging (ME-BLI) in diagnosing laryngopharyngeal reflux (LPR). The study enrolled 106 patients…

Date: 2025-09-24

Exploring the relationships between clinical manifestations and sex hormones, thyroid hormones, and menstrual factors in female Parkinson’s disease patients

Abstract: Parkinson’s disease (PD) affects both sexes, but there are notable differences in its clinical manifestations and management in women. This study aimed to compare…

Date: 2025-09-24

Gait characteristics and factors associated with fall risk in patients with dementia with Lewy bodies

Abstract: To investigate the association between gait parameters and cognitive decline in patients with dementia with Lewy bodies (DLB) and evaluate the impact of gait…

Date: 2025-09-24

Incidence and risk factors of falls in older people with chronic comorbidities in community: a cross-sectional study

Abstract: To investigate the prevalence of falls among older adult individuals with comorbidities in community and to analyze the risk factors. Using multi-stage stratified random…

Date: 2025-09-24

Dynamic performance and scenario-based screening strategy of six COPD questionnaires: a cross-sectional study with prevalence-driven robustness validation

Abstract: Chronic Obstructive Pulmonary Disease (COPD) imposes a high global burden. Spirometry is the diagnostic gold standard but has accessibility barriers. Screening…

Date: 2025-09-24

Global burden of childhood Burkitt lymphoma (1990–2021): epidemiological trends, regional disparities, and projections for 2035 from the Global Burden of Disease Study

Abstract: Burkitt lymphoma (BL) is a highly aggressive pediatric B-cell lymphoma with marked geographic heterogeneity. Up-to-date global estimates are needed to inform prevention…

Date: 2025-09-24

Variants of unknown significance in fetal heart malformations: distribution and impact on prenatal decision-making

Abstract: To investigate the distribution patterns of variants of unknown significance (VUS) in fetuses with heart malformations (CHD) combined with extracardiac abnormalities and…

Date: 2025-09-24

The use of thyroid hormones in the treatment of euthyroid patients with treatment-resistant depression. Data from a survey of 5695 European national endocrine professional organization members

Abstract: Treatment-resistant depression (TRD) is most commonly defined as depression that has not responded to two different pharmacological agents used for an adequate period of…

Date: 2025-09-23