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Changes of colistin pharmacokinetics in critically ill patients due to the extracorporeal membrane oxygenation: protocol for the COL-ECMO2022 trial – a prospective, non-randomised, open-label phase IV pharmacokinetic clinical trial

Abstract: Introduction Colistin is a lipopeptide antibiotic administered as an inactive prodrug—colistin methanesulfonate (CMS). Colistin is a drug with a narrow therapeutic…

Date: 2023-07-30

Long-term neurological complications in COVID-19 survivors: study protocol of a prospective cohort study (NeurodegCoV-19)

Abstract: Background Evidence suggests an association between SARS-CoV-2 infection and worse performance on cognitive tests, and a higher risk of Parkinson’s disease (PD) and…

Date: 2023-07-30

Development of a person-centred digital platform for the long-term support of people living with an adult-onset genetic disease predisposition: a mixed-methods study protocol

Abstract: Introduction Individuals at an inherited high-risk of developing adult-onset disease, such as breast cancer, are rare in the population. These individuals require…

Date: 2023-07-30

Improving Peer Online Forums (iPOF): protocol for a realist evaluation of peer online mental health forums to inform practice and policy

Abstract: Introduction Peer online mental health forums are commonly used and offer accessible support. Positive and negative impacts have been reported by forum members and…

Date: 2023-07-30

Effect of portable HEPA filters on COVID-19 period prevalence: an observational quasi-interventional study in German kindergartens

Abstract: Objectives The aim of the study was to evaluate the effect of high-efficiency particulate air (HEPA) filters on COVID-19 period prevalence in kindergartens. Design The…

Date: 2023-07-30

Application of classic grounded theory in nursing studies: a qualitative systematic review protocol

Abstract: Introduction Classic grounded theory (CGT) is a valuable method for nursing research, but the application of CGT methodology in nursing studies has not been specifically…

Date: 2023-07-30

Enteral supplementation with high-dose docosahexaenoic acid on the risk of bronchopulmonary dysplasia in very preterm infants: a collaborative study protocol for an individual participant data meta-analysis

Abstract: Introduction Severe bronchopulmonary dysplasia (BPD) is a well-known factor consistently associated with impaired cognitive outcomes. Regarding reported benefits on…

Date: 2023-07-30

Percutaneous catheter drainage versus percutaneous needle aspiration for liver abscess: a systematic review, meta-analysis and trial sequential analysis

Abstract: Objective To compare the effectiveness and safety of percutaneous catheter drainage (PCD) against percutaneous needle aspiration (PNA) for liver abscess. Design…

Date: 2023-07-30

Early recognition and management of maternal sepsis in Pakistan: a feasibility study of the implementation of FAST-M intervention

Abstract: Objective Maternal sepsis is the third leading cause of maternal mortality globally. WHO and collaborators developed a care bundle called FAST-M ( F luids, A ntibiotics,…

Date: 2023-07-30

Therapeutic outcomes with surgical and medical management for primary aldosteronism: protocol for a systematic review and meta-analysis

Abstract: Introduction Treatment strategies for primary aldosteronism (PA) include unilateral adrenalectomy and medical treatment with mineralocorticoid receptor (MR) antagonists.…

Date: 2023-07-30