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Heterologous prime-boost vaccination with VLA2001 and an ORFV-based vector enhances spike- and nucleocapsid-specific immunity in mice

Abstract: Heterologous prime–boost vaccination has emerged as a promising approach to enhance immune responses by combining vaccines with complementary mechanisms of antigen…

Date: 2025-09-18

Integration of autophagy-related genes and immune dysregulation reveals a prognostic landscape in multiple myeloma

Abstract: Autophagy is a self-renewal mechanism in which cells degrade damaged organelles or abnormal proteins through lysosomes. This process eliminates harmful components within…

Date: 2025-09-17

Association between eating behavior patterns and the therapeutic efficacy of GLP-1 receptor agonists in individuals with type 2 diabetes: a multicenter prospective observational study

Abstract: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used to improve glycemic control and induce weight loss in individuals with type 2 diabetes (T2D), yet…

Date: 2025-09-17

Hashimoto’s thyroiditis and thyroid hormone sensitivity in euthyroid individuals: their association with carotid plaque in northeast China

Abstract: Carotid plaque is a hallmark of systemic atherosclerosis, which underlies the pathology of cardiovascular and cerebrovascular events. Both thyroid hormones and…

Date: 2025-09-17

Impact of temperature trend-defined seasonality on psoriasis treatment outcomes: a multicenter longitudinal study

Abstract: Psoriasis severity and symptoms are widely known to vary seasonally. However, evidence on the impact of seasonality on treatment outcomes is limited, with vague season…

Date: 2025-09-17

The impact of shared decision making on transitional preparation in children with recurrent pneumonia

Abstract: This study evaluates the impact of Shared Decision-Making (SDM) on transitional preparation in children with recurrent pneumonia, highlighting its relevance to precision…

Date: 2025-09-17

Analysis of NEC cases registered in the human milk bank database

Abstract: Necrotizing enterocolitis (NEC) remains a major cause of morbidity and mortality in extremely low birth weight infants (ELBWIs), despite widespread donor human milk…

Date: 2025-09-17

Disruption of CDK5 regulatory subunit 1, p35, limits immunosuppressive M2 macrophages while maintaining functional M1 macrophages

Abstract: Macrophage polarization into M1 or M2 phenotypes is a complex process influenced by various factors. However, existing literature and ongoing research support the view…

Date: 2025-09-17

Performance analysis of EAC joint GMP inspections (2016–2022): a pathway to strengthening regulatory systems and building capacity in Africa’s less resourced authorities

Abstract: National Regulatory Authorities have the responsibility of ensuring that pharmaceutical manufacturers comply with Good Manufacturing Practices (GMP) to ensure that…

Date: 2025-09-17

Nomogram for predicting early olfactory dysfunction in obstructive sleep apnea-hypopnea syndrome: a multicenter-based study

Abstract: To develop and validate a clinical prediction model for olfactory dysfunction in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), evaluating the combined…

Date: 2025-09-17