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Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells

Abstract: Radioresistance results in relapse and treatment failure in locally advanced colorectal cancer (CRC) patients. HMGB1 is reportedly associated with radioresistance in…

Date: 2025-10-14

Non-additive strong gene interactions cause striking differences in organ pathology and cytokine response in Leishmaniasis

Abstract: The mouse strain O20 is highly resistant to parasite Leishmania major . O20 mice differed from all resistant strains tested until now, as they harbored parasites in…

Date: 2025-10-14

Cost-effectiveness of cadonilimab plus chemotherapy vs chemotherapy alone for advanced gastric cancer: evidence to inform drug pricing in the U.S. and China

Abstract: Cadonilimab, a bispecific antibody targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), was the first agent of its…

Date: 2025-10-14

European experience of patients with HER2-positive advanced/metastatic breast cancer accessing trastuzumab deruxtecan through a named patient program: the EUROPA T-DXd study

Abstract: In January 2021, trastuzumab deruxtecan (T-DXd) received conditional approval in the European Union for the treatment of human epidermal growth factor receptor…

Date: 2025-10-14

Analysis of lymph node recurrence patterns and risk factors in locally advanced esophageal carcinoma following neoadjuvant therapy

Abstract: Although neoadjuvant therapy followed by surgery is the standard treatment for resectable locally advanced esophageal carcinoma, heterogeneity exists in neoadjuvant…

Date: 2025-10-14

Quality of life and pain severity changes over time in patients with breast cancer who were referred for palliative oncology treatment in Indonesia: a hospital-based cohort study

Abstract: Understanding quality of life (QOL) and changes in pain severity over time is important to quantify cancer patients' treatment outcomes. However, this information is…

Date: 2025-10-14

Zinc deficiency and risk of intracerebral hemorrhage: a retrospective cohort study

Abstract: Intracerebral hemorrhage (ICH) accounts for 10–20% of all strokes but contributes disproportionately to stroke-related mortality and disability. Zinc, an essential trace…

Date: 2025-10-13

Development and validation of a prediction model for hypotension after neuraxial anesthesia in preeclamptic parturients: a multicenter retrospective study

Abstract: To develop and validate a multivariate prediction model for hypotension following neuraxial anesthesia in preeclamptic parturients. This multicenter retrospective study…

Date: 2025-10-13

Comparative effectiveness and safety of tenecteplase versus alteplase for intravenous thrombolysis in acute ischemic stroke: a retrospective study

Abstract: Tenecteplase has been proposed as a practical alternative to alteplase for intravenous thrombolysis in acute ischemic stroke. Although randomised trials have…

Date: 2025-10-13

Effect of the EBM-integrated BOPPPS model on clinical competence and EBM confidence in neurology clerkships for three-year junior college medical clerks

Abstract: Neurology clerkships are critical for clerks’ transition from student to assistant physician, but complex neurological content and traditional lecture-based teaching…

Date: 2025-10-13