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Psychological health and wellness and the impact of 6?weeks and 3?months supportive text messaging program (Wellness4MDs) among physicians and medical learners in Canada: a longitudinal study

Abstract: Physicians and medical learners face high rates of burnout, anxiety, and depression due to the demanding nature of their work. Many are reluctant to seek support because…

Date: 2025-09-04

Integrated bioinformatics and machine learning identify S100A9 and VGLL1 as hub genes for schizophrenia

Abstract: Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with unclear etiology, involving complex interactions between genetic and environmental factors. Current…

Date: 2025-09-04

Revisiting lean healthcare: adopting value stream mapping from manufacturing

Abstract: The application of lean thinking in healthcare has gained momentum in recent years, yet its implementation continues to face persistent challenges. Among these, staff…

Date: 2025-09-04

Microbial profile and antimicrobial resistance patterns of ocular infection pre/during and post the COVID-19 pandemic

Abstract: This research investigated the distribution characteristics and antimicrobial resistance patterns of pathogenic microorganisms in patients with ocular infection…

Date: 2025-09-04

Global, regional, and national burden of cataract among older adults from 1990 to 2021: a comprehensive analysis based on the global burden of disease study 2021

Abstract: To assess the global, regional, and national burden of cataract among individuals aged 60 years and older from 1990 to 2021, and to examine disparities by age, sex,…

Date: 2025-09-04

Novel RNA-methylase HNRNPC promotes gastric cancer tumorigenesis by triggering the lactate-induced ferroptosis resistance

Abstract: Emerging evidence gradually indicates that lactate and iron-induced cell death plays important role in gastric cancer (GC) progression. Here, this study focused on the…

Date: 2025-09-04

Loss of ATG5 impairs CD4+ T cell activation and promotes anti-tumor responses

Abstract: Macroautophagy (hereafter called autophagy) is an ancient catabolic process that delivers bulky cargo to lysosomal degradation. The autophagic pathway is regulated by…

Date: 2025-09-04

Phase-specific mortality risk of serum lactate thresholds in very low birth weight infants with late-onset sepsis: a retrospective cohort study

Abstract: Late-onset sepsis (LOS) in very low birth weight (VLBW) infants confers substantial mortality risk. While lactate monitoring is standard, validated prognostic thresholds…

Date: 2025-09-04

Machine learning-based nomogram predicts heart failure risk in elderly relapsed/refractory multiple myeloma patients receiving carfilzomib-based therapy

Abstract: To develop and validate a machine learning-based nomogram for predicting heart failure (HF) in elderly patients with relapsed/refractory multiple myeloma (RRMM)…

Date: 2025-09-03

Patient involvement in treatment decisions is associated with increased therapy satisfaction in Hidradenitis suppurativa

Abstract: Hidradenitis suppurativa (HS) is a painful and disfiguring chronic inflammatory skin disease. Despite many efforts over the past decade to improve the care of patients…

Date: 2025-09-03