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Association between TyG index and long-term mortality of critically ill patients: a retrospective study based on the MIMIC Database

Abstract: Objective To evaluate the association of triglyceride–glucose (TyG) index on admission with outcomes of critically ill patients. Design A retrospective study. Setting A…

Date: 2023-05-24

Accelerating clinical development of a live attenuated vaccine against Salmonella Paratyphi A (VASP): study protocol for an observer-participant-blind randomised control trial of a novel oral vaccine using a human challenge model of Salmonella Paratyphi A infection in healthy adult volunteers

Abstract: Introduction This is the first efficacy study of an oral live attenuated vaccine against Salmonella Paratyphi A using a human challenge model of paratyphoid infection. S…

Date: 2023-05-24

Pre-emptive coinfiltration of dexamethasone palmitate emulsion with ropivacaine for postoperative pain in patients undergoing major spine surgery: a study protocol for a prospective, randomised controlled, multicentre trial

Abstract: Introduction Patients undergoing major spine surgery usually experience moderate-to-severe postoperative pain. It has been shown that dexamethasone as an adjunct to…

Date: 2023-05-24

Mapping the evidence on assessment of fitness to work at heights: a scoping review protocol

Abstract: Introduction Falls from height are a leading cause of serious injury and fatality globally. In South Africa, work at heights is regulated by occupational health and…

Date: 2023-05-24

Ultrasound-guided pulsed radiofrequency versus dry needling for pain management in chronic neck and shoulder myofascial pain syndrome patients at a tertiary hospital in China: a randomised controlled trial protocol

Abstract: Introduction Myofascial pain syndrome (MPS), especially in the neck and shoulder region, is one of the most common chronic pain disorders worldwide. Dry needling (DN)…

Date: 2023-05-24

Train Smart Study: protocol for a randomised trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults

Abstract: Introduction Regular aerobic exercise is associated with improved cognitive function, implicating it as a strategy to reduce dementia risk. This is reinforced by the…

Date: 2023-05-24

Association between serum uric acid and measures of adiposity in Chinese adults: a cross-sectional study

Abstract: Objective The purposes of the study were to investigate the detailed association of serum uric acid (SUA) with visceral fat area (VFA) and body fat percentage (BFP) as…

Date: 2023-05-24

Protocol for a systematic review and meta-analysis assessing conservative versus liberal intravenous fluid administration in patients with sepsis or septic shock at risk of fluid overload

Abstract: Introduction Intravenous crystalloid fluid resuscitation forms a crucial part of the early intervention bundle for sepsis and septic shock, with the Surviving Sepsis…

Date: 2023-05-24

Medication use and comorbidities in an increasingly younger osteoarthritis population: an 18-year retrospective open-cohort study

Abstract: Objectives As understanding of the pathogenesis and treatment strategies for osteoarthritis (OA) evolves, it is important to understand how patient factors are also…

Date: 2023-05-24