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IgT and IgD dominance in the teleost central nervous system

Abstract: Although initially described as an immune-privileged site, the central nervous system (CNS) is now known to harbor a resident immune system, composed of different innate…

Date: 2025-08-29

c-Met inhibitor NVP-BVU972 induces antiviral protection and suppresses NF-?B-mediated inflammation

Abstract: Inhibiting viral replication and limiting NF-?B-driven inflammation simultaneously is essential for better antiviral therapy, highlighting the urgent need for a single…

Date: 2025-08-29

Bone marrow-derived extracellular vesicles from multiple myeloma patients promote adaptive immune dysfunction via HLA-G, PD-1, and PD-L1

Abstract: Extracellular vesicles (EVs) are critical mediators of intercellular communication and contribute to cancer progression and immune regulation. We characterized EVs…

Date: 2025-08-28

African regional and national burden of diabetes mellitus and its attributable risk factors from 1990 to 2021: results from the global burden of disease study 2021

Abstract: Diabetes mellitus (DM), a chronic disease characterized by hyperglycemia, has become a global health concern. This study evaluates the burden of DM in the African region…

Date: 2025-08-28

Serum proteomics analysis of lung transplant patients receiving different induction therapies

Abstract: Induction therapy is widely used in lung transplantation to control the host alloresponse, reducing acute cellular rejection and improving graft survival. Despite its…

Date: 2025-08-28

Serum cytokine profiles at near term-equivalent age and their association with neurodevelopmental outcomes in preterm infants: an exploratory study

Abstract: While early-life cytokine profiles have been linked to neurodevelopmental outcomes in preterm infants, their prognostic value is limited by clinical instability and…

Date: 2025-08-28

The protective role of steroids on coronary arteries in the acute phase of Kawasaki disease for high risk patients: a retrospective study

Abstract: The incidence of coronary artery aneurysms in Kawasaki disease has been increasing for reasons that remain unclear. Recently the use of corticosteroids in KD has been…

Date: 2025-08-28

Use of HLA desensitization in the management of renal transplant recipients in Europe

Abstract: A significant challenge in kidney transplantation is overcoming immunological barriers such as human leukocyte antigen (HLA) incompatibilities. The presence of anti-HLA…

Date: 2025-08-28

Development of fully automated deep-learning-based approach for prediction of sentinel lymph node metastasis in breast cancer patients using ultrasound imaging

Abstract: This study aimed to develop a novel predicting model based on deep learning (DL) to predict sentinel lymph node (SLN) metastasis in breast cancer (BC) patients using…

Date: 2025-08-28

Active disease and its associated factors among patients with inflammatory bowel disease in Addis Ababa, Ethiopia: a hospital-based cross-sectional study

Abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract, primarily classified into Crohn’s disease (CD) and ulcerative…

Date: 2025-08-28