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Changes in self-reported alcohol consumption at high and low consumption in the wake of the COVID-19 pandemic: a test of the polarization hypothesis

Abstract: The Coronavirus Disease 2019 (COVID-19) pandemic and associated public health measures impacted alcohol use. It was hypothesized that the COVID-19 pandemic led to a…

Date: 2025-09-17

Factors influencing the benefits of pulmonary rehabilitation in older adults with chronic obstructive pulmonary disease: a prospective study

Abstract: To investigate the benefits of pulmonary rehabilitation (PR) in older adults with stable chronic obstructive pulmonary disease (COPD) and analyze its influencing…

Date: 2025-09-17

Exploring life skills, research adaptation, and team building among basic medical postgraduates

Abstract: Under the background of “basic top-notch 2.0” plan, taking the graduate students of Xiangya School of Basic Medical Sciences, Central South University as an example, to…

Date: 2025-09-17

Integrating bioinformatics and experimental validation to reveal a novel VRK score as a prognostic and therapeutic biomarker in hepatocellular carcinoma

Abstract: Vaccinia-related kinase (VRK) family genes play a multifunctional role in tumor development. However, the role of VRK family genes in hepatocellular carcinoma (HCC)…

Date: 2025-09-17

The impact of informal caregiving on the mental health of health care workers during the COVID-19 pandemic—cross-sectional and longitudinal results from the VOICE study

Abstract: The COVID-19 pandemic increased psychological distress among health care workers (HCWs). Those with informal caregiving responsibilities (ICs) may be especially…

Date: 2025-09-17

Adolescent substance use in Costa Rica: findings from a national survey among secondary school students

Abstract: Adolescent substance use (alcohol, tobacco, e-cigarette, marijuana, and other illegal drug use) is a growing public health concern in Latin America. In Central America,…

Date: 2025-09-17

HOXB7 drives bladder cancer progression via H-Ras/ERK signaling: a potential therapeutic target and prognostic biomarker

Abstract: Bladder cancer (BC) is a common malignancy characterized by high recurrence and poor prognosis. HOXB7, a member of the HOX gene family, is aberrantly expressed in…

Date: 2025-09-17

The clinical features and initial pharmacotherapeutic options of children with Tic disorders

Abstract: Tic disorders (TD) are common childhood neurodevelopmental conditions, characterized by diverse manifestations, leading to misdiagnosis and delayed therapy. Timely…

Date: 2025-09-17

Intestinal SURF4 in dyslipidaemia and female-specific metabolic disorders: insights from rats with polycystic ovary syndrome

Abstract: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and metabolic disturbances, including…

Date: 2025-09-17

Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets

Abstract: Pregnancy induces profound immunological adaptations necessary to support fetal development while preserving maternal health. However, the systemic dynamics of…

Date: 2025-09-17