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Gain-of-function mutations in KATP channel subunits compromise colonic tight junction integrity and epithelial homeostasis in murine models of Cantú syndrome

Abstract: Cantú syndrome (CS) is a rare genetic disorder caused by gain-of-function (GOF) mutations in the KCNJ8 (Kir6.1) or ABCC9 (SUR2) subunits of ATP-sensitive potassium…

Date: 2025-09-11

Transcriptome-based immune subtypes reveal the heterogeneity of tumor microenvironment in pediatric B-cell acute lymphocytic leukemia

Abstract: Increasing evidence highlights the important role of the tumor microenvironment (TME) in B-cell acute lymphocytic leukemia (B-ALL). Our study aimed to stratify B-ALL…

Date: 2025-09-10

A retrospective analysis of inotuzumab ozogamicin usage in adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia

Abstract: The treatment of B-cell acute lymphoblastic leukemia (ALL) in India involves multi-agent chemotherapy and central nervous system (CNS) prophylaxis, but…

Date: 2025-09-10

Retrospective analysis of the efficacy and safety of anlotinib plus sintilimab (anti-PD-1) as maintenance therapy in advanced pediatric solid tumors

Abstract: Advanced solid tumors in children have limited maintenance treatment options. This study assessed the effectiveness and safety of anlotinib in conjunction with…

Date: 2025-09-10

Genetic and phenotypic heterogeneity of type 2 diabetes across Russian ancestry groups

Abstract: Type 2 diabetes mellitus (T2D) is a highly polygenic disease involving multiple biological pathways. Genetic ancestry may influence the predominant mechanisms driving…

Date: 2025-09-10

Oolong tea attenuates neuroinflammation by modulating the microbiota-gut-brain axis in a rat model of autism

Abstract: Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with limited effective treatments. Emerging evidence implicates dysregulation of the…

Date: 2025-09-10

Analysis of growth and development levels and influencing factors in children aged 3–12?years in a certain region: a cross-sectional study

Abstract: This multi-center cross-sectional study aims to analyze growth and development levels and identify factors influencing these parameters among children aged 3–12?years in…

Date: 2025-09-10

Evaluation of a pediatric post-acute sequelae of SARS-CoV-2 index score

Abstract: This study aims to assess the performance of the Researching COVID-19 to Enhance Recovery (RECOVER) initiative's proposed post-acute sequelae of COVID-19 (PASC) index in…

Date: 2025-09-10

Securinine, a novel alkaloid, regulates cell cycle and EMT in gastric cancer by inducing iron-dependent cell death

Abstract: Gastric cancer remains one of the most prevalent and lethal cancers worldwide, with its insidious onset hindering early diagnosis and effective treatment. Despite…

Date: 2025-09-10

Archimedes navigation system-guided bronchoscopic trans-parenchymal nodule access for peripheral lung nodules: a single-center experience

Abstract: Peripheral pulmonary lesions (PPLs) present diagnostic challenges because of their small size and distal airway location, often requiring invasive surgical biopsies. The…

Date: 2025-09-10