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Two rare mutations in homozygosity synergize to silence TREX1 in Aicardi-Goutières syndrome

Abstract: Background: Aicardi-Goutières syndrome (AGS) is a rare monogenic type I interferonopathy characterized by dysregulated inflammation and tissue damage that primarily…

Date: 2025-02-21

Use of CatBoost algorithm to identify the need for surgery in infants with necrotizing enterocolitis

Abstract: Background: Early identification of infants with necrotizing enterocolitis (NEC) at risk of surgery is essential for an effective treatment. This study aims to clarify…

Date: 2025-02-21

A bibliometric analysis of the advance of artificial intelligence in medicine

Abstract: Introduction: The integration of artificial intelligence (AI) into medicine has ushered an era of unprecedented innovation, with substantial impacts on healthcare…

Date: 2025-02-21

Association of systemic immune inflammation index with depression among adult type 2 diabetic patients in a tertiary hospital, Ethiopia, 2022

Abstract: Background: The inflammatory and hormonal aspects of T2DM can influence the development or worsening of depressive symptoms. While most of the burden had due…

Date: 2025-02-21

“Blood is thicker than water” - experiences and perspectives of family caregivers of people living with severe mental illness at Holy Water traditional healing sites, Addis Ababa, Ethiopia

Abstract: Background: Family caregivers of people with severe mental illness (SMI) are the backbone of the mental health care system in resource-limited family centered cultural…

Date: 2025-02-21

Impact of hyperhydration on fluid overload and hematopoietic cell transplant after post-transplant cyclophosphamide-based graft-versus-host-disease prophylaxis

Abstract: Introduction: Hemorrhagic cystitis (HC) is an early complication after hematopoietic cell transplant (HCT) with post-transplant cyclophosphamide (PTCy). Hyperhydration…

Date: 2025-02-20

Aclacinomycin enhances the killing effect of allogeneic NK cells on acute myeloid leukemia cells by inducing immunogenic cell death

Abstract: Introduction: Natural killer (NK) cells, which exert spontaneous cytotoxicity against infectious diseases and cancer, also play an important role in leukemia therapy.…

Date: 2025-02-20